Antioksidacijska svojstva derivata kumarina i njihovo antifungalno djelovanje prema najvažnijim mikotoksikogenim plijesnima iz hrane
In this work synthesis of coumarin derivatives with potential antifungal and antioxidant activity was performed. According to recent research work, synthethic modification of 7-hydroxy-4-methylcoumarin can improve its antifungal and antioxidant activity. A series of new coumarin derivatives, Schiff bases, thiosemicarbazides and thaizolidinones was prepared by conventional synthetic routes. Antioxidant activity of the compounds was evaluated using DPPH radical scavenging method, which was performed spectrophotometrically, by EPR spectroscopy (DPPH radical and galvinoxyl radical) and phosphomolybdenum method. The results indicated that the substitution of hydroxyl group of 7-hydroxy-4-methylcoumarin with dihidroxyphenyl or thiosemicarbazide group can increase an antioxidant activity of the starting compound. Antifungal investigation of coumarin derivatives against most relevant mycotoxigenic food molds, Aspergillus flavus, A. ochraceus, Fusarium graminearum and F. verticillioides, was also performed. The results revealed strong antifungal properties of the derivatives, Schiff bases especially. Several compounds effected a 100% inhibition against selected fungi, especially Schiff bases containing hydroxyl groups. Substitution of 7-hydroxy-4-methylcoumarin in position 7 can increase antifungal activity of the starting compound, especially against F. verticillioides. Compounds showing potent antioxidant and antifungal activity were Schiff bases with dihydroxyphenyl substituents and thiosemicarbazides with unsubstituted or substituted phenyl groups.
|Creator||Molnar, Maja (Search Europeana for this person)|
|Collection||Josip Juraj Strossmayer University of Osijek. FACULTY OF FOOD TECHNOLOGY. Department of Applied Chemistry and Ecology. Sub-department of Chemistry and Ecology.|
|Subject Terms||BIOTECHNICAL SCIENCES. Food Technology. Engineering., Chemistry. Crystallography. Mineralogy, coumarin, synthesis, antifungal activity, antioxidant activity|
|Provider||National and University Library in Zagreb|